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Matlab can also be used from C++ and fortran as a library of maths and graphics routines. Also C++ and fortran code can be called from within matlab.AnInterface Guide is online. Current examples are in /usr/local/apps/matlab/matlabR2007a/extern/examples/ on our Linux servers. Local users using these files on the linux serversshould note that some local configuring may be required - see Matlab: configuring mex page.
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The methodology builds upon that already implemented in MLwiN which is described in the MLwiN manuals. The training materials are written in MATLAB. and are available as free-standing programs. They are designed to interface with MLwiN in terms of data transfer but have their own graphical user interfaces for setting up models and displaying results. There is a set of training materials (PDF, 791kB). which provides an introduction to the methodology and a guide to using the software.
The methodology builds upon that already implemented in MLwiN version 2.02 which is described in the MLwiN manuals. The training materials are written in MATLAB and are available as free-standing programs. They are designed to interface with MLwiN in terms of data transfer but have their own graphical user interfaces for setting up models and displaying results.
(a) Supervised machine learning (trained using live cells stained with DRAQ5 to determine the DNA content) allows for robust label-free prediction of the DNA content of live cells based only on brightfield and darkfield images. We find a Pearson correlation of r=0.7860.010 (error bars indicate the s.d. obtained via 10-fold cross-validation) between actual DNA content and predicted DNA content using regression (see Methods section). We believe this reduction in correlation from the value of 0.896 obtained for fixed cells to be a consequence of the greater variability of the uptake of the live DNA dye compared with the staining achieved with fixed cells. Despite the reduction in correlation a value of 0.786 is still high enough to make this a viable method for the cell cycle analysis of live cells. As previously, we determine the fraction of cells in the G1, S and G2/M phases using the Watson pragmatic curve fitting algorithm. (b) We predict an increase of 13.4% in the G2/M phase after the cells were treated with 50μM Nocodazole, which is in good agreement with the average increase of 19.011.0% in G2/M as was found for three independent cell populations under the same treatment (Supplementary Figure 3). The phase-blocked data set was not labelled with any marker. Instead, we trained our machine learning algorithm on the untreated data set, which was labelled with a DRAQ5 DNA stain (see a) and used the trained machine learning algorithm to predict the DNA stain of the blocked cells.
The same basic strategy can be readily adapted to measure other phenotypes, making this a generally useful approach for label-free, single-cell phenotyping in the modern biological laboratory. The method can also be used retrospectively on data sets that do not have the necessary stains for phenotype identification, providing an annotated data set is available to train the algorithms (see Methods section). While current imaging flow cytometers do not have physical cell-sorting capabilities, and for now our approach is suited to experimental contexts where samples are analysed only, this approach may offer the possibility to entirely avoid any fluorescent stain and opens up the perspective for a new generation of image flow cytometers that could operate without fluorescence channels.
The rest of this paper is organized as follows. Section 2 briefly reviews theoretical aspects in topology optimization with focus on the density-based approach. Section 3 introduces 3D finite element analysis and its numerical implementation. Section 4 presents the formulation of three typical topology optimization problems, namely, minimum compliance, compliant mechanism, and heat conduction. Section 5 discusses the optimization methods and their implementation in the code. Section 6 shows the numerical implementation procedures and results of three different topology optimization problems, several extensions of the top3d code, and multiple alternative implementations. Finally, Section 7, offers some closing thoughts. The top3d code is provided in Appendix C and can also be downloaded for free from the website:
By default, the code solves a minimum compliance problem for the cantilevered beam in Fig. 4. The prismatic design domain is fully constrained in one end and a unit distributed vertical load is applied downwards on the lower free edge. Figure 4 shows the topology optimization results for solving minimum compliance problem with the following Matlab input lines:
The use of top3d is demonstrated through several numerical examples. These examples include problems with a variety of boundary conditions, multiple load cases, active and passive elements, filters, and continuation strategies to mitigate convergence to a local minimum. The architecture of the code allows the user to map node coordinates of node degrees-of-freedom boundary conditions. In addition, the paper provides a strategy to handle large models with the use of an iterative solver. For large-scale finite-element models, the iterative solver is about 30 times faster than the traditional direct solver. While this implementation is limited to linear topology optimization problems with a linear constraint, it provides a clear perspective of the analytical and numerical effort involved in addressing three-dimensional structural topology optimization problems. Finally, additional academic resources such the use of MMA and SQP are available at
A complete copy of the MATLAB software must be obtained before it can be installed. The MATLAB software is available to licenses holders on both a DVD and through the The MathWorks website. In addition to the software a file installation key is required for installation. It is possible to install MATLAB either with the matlabAUR package or from the MATLAB installation software directly. The advantage of the matlabAUR package is that it manages dependencies and some of the nuances of the installation process while installing directly from the MATLAB installation software can be done by regular users to their home directories.
Matlab might complain that it cannot find a package. Look at the package name and install it with Pacman, or in the case of x86_64 there are some libraries only in AUR. matlabAUR and matlab-dummyAUR packages contain a list of up-to-date dependencies for the newest Matlab version.
Make sure the correct support package add-ons are installed (webcam or OS Generic Video Interface for example). If running matlab as a user, make sure your user has write permissions to wherever the support packages are being downloaded and installed.
If calls from MATLAB or Simulink to mex (e.g. rapid accelerator) fail with the error *.mexa64 is not a MEX file, even though the resulting file is usable, it may help to edit in either matlab/bin/ or /.matlab7rc.sh by changing the LDPATH_PREFIX variable from its empty default: [6]
In some cases on recent Arch systems matlab is unable to export .mlsettings files, preventing toolbox and some matlab settings from being saved to disk and persisted. These cases come from matlab trying to hard link new files from /tmp directly to the preferences directory (usually /.matlab/release where release is the matlab version, e.g. R2021b). As a workaround, run matlab with the $TMPDIR environment variable set to a folder on the same file system as the preferences directory. [7]
MATLAB can be run within a systemd-nspawn container to maintain a static system and avoid the library issues that often plague matlab installs after significant updates to libraries in Arch. Refer to Systemd-nspawn for detailed information on setting up such containers.
In the event of a foot-and-mouth disease (FMD) incursion, response strategies are required to control, contain, and eradicate the pathogen as efficiently as possible. Infectious disease simulation models are widely used tools that mimic disease dispersion in a population and that can be useful in the design and support of prevention and mitigation activities. However, there are often gaps in evidence-based research to supply models with quantities that are necessary to accurately reflect the system of interest. The objective of this study was to quantify values associated with the duration of the stages of FMD infection (latent period, subclinical period, incubation period, and duration of infection), probability of transmission (within-herd and between-herd via spatial spread), and diagnosis of a vesicular disease within a herd using a meta-analysis of the peer-reviewed literature and expert opinion. The latent period ranged from 1 to 7 days and incubation period ranged from 1 to 9 days; both were influenced by strain. In contrast, the subclinical period ranged from 0 to 6 days and was influenced by sampling method only. The duration of infection ranged from 1 to 10 days. The probability of spatial spread between an infected and fully susceptible swine farm was estimated as greatest within 5 km of the infected farm, highlighting the importance of possible long-range transmission through the movement of infected animals. Finally, while most swine practitioners are confident in their ability to detect a vesicular disease in an average sized swine herd, a small proportion expect that up to half of the herd would need to show clinical signs before detection via passive surveillance would occur. The results of this study will be useful in within- and between-herd simulation models to develop efficient response strategies in the event an FMD in swine populations of disease-free countries or regions. 2ff7e9595c
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